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分组方法中如何处理 UVCB 和杂质？
问题（中文）
分组方法中如何处理 UVCB 和杂质？
Question (EN)
How are UVCBs and impurities handled in the grouping approach?
中文内容由 Google Cloud Translation 自动生成，仅供参考；请以英文原文为准。问答资料来自欧盟化学品管理局（ECHA）官方网站。
答案（中文）
通常，ECHA 会使用注册档案中的所有物质身份信息来生成结构并执行筛选方案。然而，结构相似性仅考虑高于给定浓度阈值的成分（包括杂质）。关于 UVCB 的分组，如果它们能够用一个或一组代表性结构来表示，则将其视为定义明确的物质。此外，基于横向比较或类别的分组不受物质成分的影响。
Answer (EN)
Generally ECHA is using all substance identity information in registration dossiers for generating structures and for executing the screening scenarios. However, structural similarity only considers constituents (including impurities) above a given concentration threshold. With regard to the grouping of UVCBs, they are handled like well defined substances if they can be structurally represented with a representative structure or possibly a set of representative structures. Moreover, grouping based on read-across or categories is not affected by the substance composition.