类似物质的信息是否会影响具有自己数据集的物质的手动筛选结果？

类似物质的信息是否会影响具有自己数据集的物质的手动筛选结果？

Can information on similar substances influence the outcome of manual screening for substances that have their own dataset?

当有证据表明预期存在类似危害时，物质会被分组，然后在人工筛选中将所有物质的数据集放在一起考虑。这种方法可以在一定程度上缓解组中一种或多种物质信息不足的问题，因为原则上，如果不生成更多信息，就无法单独评估这些物质。然而，如果有关于同一物质的可靠实验数据，并且这些数据证明疑似问题并不成立，那么这些数据将推翻来自类似物质的任何矛盾证据（甚至会质疑分组的稳健性）。

When substances are grouped because there is evidence that similar hazards are to be expected, then the datasets of all substances are considered together in manual screening. This approach may, to some extent, alleviate issues with information deficiencies for one or more of the substances in the group that in principle could not be assessed on their own without generating further information. However, if there are reliable experimental data on the same substance and these prove that the suspectd concern does not hold then these data will overrule any conflicting evidence from similar substances (and even question the robustness of the grouping).