与附件 XIV 的内在特性相关的终点是否比其他终点更为关键？

与附件 XIV 的内在特性相关的终点是否比其他终点更为关键？

Are end points related to the intrinsic properties of Annex XIV more critical than other end points?

如果物质设有阈值，则需要证明附件XIV中提到的危害终点相关风险已得到充分控制。如果物质没有阈值，则需要证明其已尽可能地将排放和暴露降至最低。因此，化学品安全报告 (CSR) 应重点关注附件XIV的终点，但为了将风险与替代品进行比较，可能需要其他终点的信息。替代品应能够降低对人类健康和环境的总体风险。因此，不仅要考虑附件XIV终点带来的风险，还要考虑附件XIV物质及其替代品的所有其他可能风险。

If the substance has a threshold you need to demonstrate that the risks associated for the hazard endpoint mentioned in Annex XIV are adequately controlled. If the substance does not have a threshold, you need to demonstrate minimisation of emissions and exposure as far as possible. The Chemical Safety Report (CSR) should therefore focus on the Annex XIV endpoint but information on other endpoints might be necessary for comparing the risks with the alternatives. The alternatives should result in reduced overall risks to human health and the environment. Therefore, it is important not only to consider the risks arising from the Annex XIV endpoint but also on all other possible risks from the Annex XIV substance and the alternatives.