ECHA 在档案中检查的目标终点是什么？

ECHA 在档案中检查的目标终点是什么？

What are the target endpoints that ECHA is checking in the dossiers?

根据欧洲化学品管理局的综合监管策略，对于每年生产或进口超过 100 吨的物质，其提交的卷宗合规性检查主要关注八个关键信息要求（或属性）：遗传毒性、重复剂量毒性、产前发育毒性、生殖毒性、致癌性、长期水生毒性、生物降解和生物累积性。目标是关注对人类健康和环境最重要的信息要求（或属性），特别强调那些与物质的持久性、生物累积性/移动性和毒性（PBT/PMT）或致癌性、致突变性或生殖毒性（CMR）特性相关的信息要求（或属性）。有关合规性检查策略的更多信息，请参阅合规性检查页面。

Under ECHA’s Integrated Regulatory Strategy, the compliance check of dossiers submitted for substances manufactured or imported at more than 100 tonnes per year mainly focuses on eight key information requirements (or properties):genotoxicityrepeated dose toxicitypre-natal developmental toxicity reproductive toxicitycarcinogenicitylong-term aquatic toxicitybiodegradation and bioaccumulation.The goal is to focus on the information requirements (or properties) that matter most for human health and the environment, with special emphasis on those which are related to the persistent, bioaccumulative/mobile and toxic (PBT/PMT) or carcinogenic, mutagenic or toxic to reproduction (CMR) properties of a substance.More information on the strategy on compliance checks is available at compliance checks page.