ECHA 如何进行分组？

ECHA 如何进行分组？

How is the grouping done by ECHA?

初始分组主要使用基于IT的算法，并遵循两种广泛且互补的方法：结构相似性，使用注册档案和C&L通知中的物质身份信息；以及注册人通过横向关联和类别关联方法以及来自外部来源（例如OECD类别）的类别关联在物质之间建立的关联。算法生成的组由化学家验证，并通过组评估重新考虑组成员资格。在已注册物质的总体范围内，围绕预先选定的物质（称为“种子”）识别结构相似的物质。种子的例子包括CLP法规附件VI、候选清单或CoRAP中列出的物质，这些物质已经存在已知或潜在的危害。另一个分组的起点可以是具有特定用途或功能且可能暴露的物质。请注意，这些方法与REACH附件XI第1.5节定义的分组不同，因此根据该要求，它们不构成经过验证的横向关联和类别信息。

The initial grouping is done primarily using IT-based algorithms and following two broad, complementary methods: structural similarity, which uses the substance identity information in registration dossiers and C&L notifications; and associations made by the registrants between substances through read-across and category approaches as well as category associations from external sources (e.g. OECD categories). The algorithmically generated groups are verified by chemists and group membership is reconsidered through the group assessment. Structurally similar substances are identified within the universe of registered substances around pre-selected substances known as ‘seeds’. Examples of seeds are substances in Annex VI to the CLP Regulation, in the Candidate List or listed in the CoRAP, for which there is already an identified or potential hazard. Another starting point for grouping could be a substance that has a certain type of use or function with a potential for exposure. Note that these methods are different from grouping as defined in Section 1.5 of Annex XI to REACH and therefore do not constitute validated read-across and category information according to that requirement.